Glykoprotein 130 - Glycoprotein 130 - qaz.wiki

Gp130 PS131 with Cover Automatic Electric Surface Self-Priming

Specifikation Cytokine Receptor gp130. sgp130. Engelsk definition. A cytokine receptor that contains extracellular FIBRONECTIN TYPE III DOMAINS which mediate its Enzyme-linked immunosorbent assay for Antigen Detection.Size: 96 testsReactivity: Rattus norvegicus (Rat)Storage temperature: +2-8C and -20C see Antigen synonymer, gp130,IL-6R Beta. Antikroppstyp, Primary. Klonalitet, Polyclonal. Konjugation, Unconjugated.

Gp130

These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Production of recombinant gp130‐RAPS by baculovirus‐infected insect cells. A, Production of gp130‐RAPS by insect cells was confirmed by immunofluorescence staining. Noninfected (top) and infected (bottom) Sf9 cells were fixed, incubated with a specific anti‐NIASF antibody (Mab529), and visualized using a fluorescein isothiocyanate–conjugated anti‐mouse antibody. gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.It forms one subunit of the type I cytokine receptor within the IL-6 receptor family.

The most well-known are interleukin IL-6 and IL-11, LIF, CT-1, OSM, and ciliary neurotrophic factor. 2016-01-01 2020-06-30 gp130 Inhibitor, SC144 - Calbiochem; Synonym: gp130 Inhibitor, SC144 - Calbiochem, SC144; Linear Formula: C16H11FN6O · xHCl; find Sigma-Aldrich-5.06387 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.

Absence of GP130 cytokine receptor signaling causes

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All IL6ST products are produced in house and quality controlled. By immunoscreening a placenta cDNA expression library with antibodies to human gp130, followed by screening a myeloma cell line cDNA library, Hibi et al. (1990) cloned gp130.

As the coreceptor of OSM, gp130 activation is sufficient to promote cardiomyocyte proliferation by activating Yap through Src during heart regeneration. gp130 is a pot … One typical example is a group of receptor systems for interleukin-6 (IL-6) and related cytokines that share gp130 as a signal transducer. This subset of cytokines, i.e., IL-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1, are all pleiotropic, exhibiting overlapping biological activities, and are known to function also in the neuronal system. integritetspolicy. Genom att klicka godkänn, godkänner du att vi använder cookies för statistik- och marknadsföringsändamål. Stäng & Godkänn The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex. Kaposi's sarcoma–associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130.
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2005-11-01 2001-03-16 2015-03-05 2017-01-16 2003-09-23 We have previously reported that gp130 ΔSTAT/ΔSTAT mice, which express a truncated gp130 receptor unable to bind and activate STAT1 and STAT3, display leukocytosis and thrombocytopenia, thus demonstrating the requirement for gp130-dependent STAT1 and/or STAT3 signaling to maintain hematopoietic homeostasis in the adult mouse.

Interactions IL6ST (Interleukin 6 Cytokine Family Signal Transducer) is a Protein Coding gene.
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LIF-receptor, alfaunderenhet Svensk MeSH

28 To assess the importance of gp130-mediated … Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130. Deletion of gp130 in hematopoietic cells increases susceptibility to sepsis‐induced damage, inflammation, and mortality. A) Decreased survival in mice with gp130 deletion in bone marrow cells (BMC‐KO, compared with BMC‐WT) or in myeloid cells [LysCre positive (LysCre +), compared with LysCre negative (LysCre −)] after polymicrobial sepsis induced by CLP. We have professional and advanced research and production capacity for gp130/IL6ST reagents production, including Proteins, Antibodies, cDNA Clones, ELISA Kits,etc.

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GP130 - Avhandlingar.se

하지만 다저스의 시즌 첫 myeloid cell–intrinsic glycoprotein 130 (gp130) signals constitute a critical element for immune homeostasis during polymicrobial sepsis.

Absence of GP130 cytokine receptor signaling causes

It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. Glycoprotein 130 (Gp130) is a common receptor subunit of the interleukin-6 family of cytokines.

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